解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Subcutaneous implantation of a silastic tubing containing crystalline estradiol in castrated female rats results in a circadian rhythm of LH release. Under such conditions, blockade of serotonin (5-HT) biosynthesis by p-chlorophenylalanine (PCPA) completely inhibits the afternoon elevation of plasma LH. Gonadotropin p...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-99-2-496
更新日期:1976-08-01 00:00:00
abstract::Melatonin was shown to occur in rat plasma and urine after pinealectomy by bioassay, radioimmunoassay, and thin-layer chromatography. Total daily excretion of melatonin in pinealectomized rats was about 20% of control. Light-dark rhythms of plasma melatonin levels and urinary excretion rates disappeared after pinealec...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-99-2-641
更新日期:1976-08-01 00:00:00
abstract::Testicular cytosol from Sprague-Dawley rats was shown to possess an estradiol binding component which exhibited the properties of a receptor. Specific binding of estradiol by the receptor was shown, at 4C in vitro, to reach equilibrium by 6 h. That level of binding was maintained at a plateau for 18 h. Estradiol bindi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-99-2-555
更新日期:1976-08-01 00:00:00
abstract::The effect of active and passive immunization with luteinizing hormone-releasing hormone (LHRH) on serum LH and follicle-stimulating hormone (FSH) levels and the ultrastructure of the pituitary gonadotrophs was investigated in castrated male rats. Two weeks after castration, the animals were immunized with Glu1-LHRH c...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-99-1-291
更新日期:1976-07-01 00:00:00
abstract::The effect of progesterone on the secretion of LH was studied in intact and castrated immature female sheep between 12 and 42 weeks of age. (First spontaneous ovulation occurs between 30 and 50 weeks of age.) Progesterone was administered by means of Silastic capsules inserted SC to achieve circulating progesterone co...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-99-1-1
更新日期:1976-07-01 00:00:00
abstract::The effect of naloxone (N-allylnoroxymorphone), a narcotic antagonist, on the morphine blockade of ovulation was studied. Female rats were treated with morphine (50 mg/kg) at the critical period, resulting in ovulatory blockade. The administration of naloxone (0.5 mg/kg) effectively reversed the anti-ovulatory effect ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-99-1-7
更新日期:1976-07-01 00:00:00
abstract::Specific binding of human chorionic gonadotropin (hCG), and the hCG-sensitive adenyl cyclase of granulosa cells from small (1-2 mm), medium (3-5 mm), and large (6-12 mm) porcine ovarian follicles have been studied. The number of hCG-binding sites per cell (n) increases during follicle maturation without a change in th...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-99-1-42
更新日期:1976-07-01 00:00:00
abstract::Serum and pituitary thyroid-stimulating hormone (TSH) was measured by radioimmunoassay in male and female Sprague-Dawley rats from 21 through 80 days of age. In males, serum TSH levels increased progressively from days 30 through 50, and were found to be lower on days 60, 70, and 80. In females, serum TSH levels were ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-6-1365
更新日期:1976-06-01 00:00:00
abstract::A competitive protein-binding (CPB) assay, suitable for measuring corticosterone levels in 20 mul of mouse plasma or 100 mg of brain, is described. The postnatal development of adrenocortical function was determined in C57BL/10 and DBA/1 mice by CPB assay of basal and stressinduced levels of plasma corticosterone and ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-6-1434
更新日期:1976-06-01 00:00:00
abstract::Active immunization of male rabbits results in a marked increase in plasma testosterone (T) and in the fraction of T bound to circulating proteins. In order to identify the cause of the increased T levels, the half-life of T after castration, and the metabolic clearance rate (MCR) and production rate (PR) after a sing...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-5-1142
更新日期:1976-05-01 00:00:00
abstract::In order to delineate the ages of onset and decline in sensitivity to growth hormone (GH) in rats, the ability of ovine GH in vitro to stimulate amino acid uptake and protein synthesis was studied in diaphragm muscle. GH (25 mug/ml) produced a significant, but small (12-17%), stimulation of alpha-aminoisobutyric acid ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-5-1273
更新日期:1976-05-01 00:00:00
abstract::CRF activity of synthetic vasopressins and pitressin was studied in an in vitro system of cultured rat adenohypophyseal cells using direct measurement of ACTH by radioimmunoassay. Pitressin (posterior pituitary extract) induced a dose-related secretion of ACTH whereas synthetic arginine or lysine vasopressin were devo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-4-936
更新日期:1976-04-01 00:00:00
abstract::The effects of estrogens, androgens, and glucocorticoids on bone resorption were compared in organ culture. At a concentration of 10(-5) M, corticosterone, testosterone, dihydrotestosterone, dehydroepiandosterone, estradiol, ethinyl estradiol and estrone did not inhibit the release of 45Ca from 19-day fetal rat long b...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-4-1065
更新日期:1976-04-01 00:00:00
abstract::Six pony mares were ovariectomized (OVX) on day 16 of diestrus during June and July, 1972, to study short term changes in plasma luteinizing hormone (LH) concentrations. Plasma LH was higher (P less than .05) 3 days after OVX (1.76 ng/ml) than the day after OVX (1.01 ng/ml), and a gradual increase occurred over the fi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-4-958
更新日期:1976-04-01 00:00:00
abstract::Pineal denervation by superior cervical ganglionectomy (Gx) decreased high affinity binding of estradiol (E2) to the pineal cytosol of female rats and of testosterone to the cytosol of male rats by 40 and 26% and by 75 and 80%, 5 and 14 days after sugery; hormone binding remained unchanged up to 24 h after surgery. Bi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-4-849
更新日期:1976-04-01 00:00:00
abstract::The effect of the administration of sheep anti-LHRH gamma-globulin (anti-LHRHG) on the maintenance of pregnancy was investigated in rats. Nidation was confirmed by laparotomy on day 7 or 8 of pregnancy. In one experiment, rats were then injected iv with 1 ml anti-LHRHG or normal sheep gamma-globulin (NSG) daily from d...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-4-1024
更新日期:1976-04-01 00:00:00
abstract::Basal or hypothalamic extract-induced ACTH or TSH secretory capacity as well as intracellular ACTH content were assessed in cultured rat adenohypophyseal cells after various pretreatments of the donor animals. Medium and intracellular ACTH or TSH were measured by radioimmunoassay. Ten-day to 2-month adrenalectomy enha...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-3-717
更新日期:1976-03-01 00:00:00
abstract::We compared the somatomedin (SM) activity of perfusates of livers from normal and hypophysectomized (hypox) rats with and without the addition of growth hormone (GH) to the perfusions. Livers were perfused for a total of 3 hours, with a change of Waymouth's medium MB 752/l every 30 min, in a continously recirculating ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-3-606
更新日期:1976-03-01 00:00:00
abstract::Gap junctions were observed on the lateral plasma membrane of the typical thyroid epithelial cell in freeze-fracture preparations of rat thyroid gland. The gap junctions were 0.1 to 0.4 mum in diameter and were composed of closely packed, approximately 80 nm particles. They were located from 1 to 6 mum from the apical...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-3-800
更新日期:1976-03-01 00:00:00
abstract::Hypophysectomized female rats which received renal grafts of anterior pituitary (AP) or weight-matched intact controls were sampled under urethane anesthesia. Plasma growth hormone (GH) in sequential samples from each rat was measured by radioimmunoassay to determine the effect of exogenous thyrotropin-releasing hormo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-3-807
更新日期:1976-03-01 00:00:00
abstract::Studies were carried out to determine the origin of the immediate increase in plasma calcium following acute calcitonin deficiency in mature rats. Animals were pre-labelled with 45calcium 24 hours and 4 weeks before thyroparathyroidectomy (TPTX) and 1 hour, 24 hours, 2 and 4 weeks before nephrectomy and TPTX and bled ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-2-534
更新日期:1976-02-01 00:00:00
abstract::More than 150 hypothalamic fractions were reassayed for luteinizing hormone-releasing hormone (LHRH) and follicle stimulating hormone-releasing hormone (FSHRH) activities in search for LHRH and FSHRH which differ from the decapeptide (pyro)Glu-His-Trp-Ser-Try-Gly-Leu-Arg-Pro-Gly-NH2 (I). Among the porcine fractions te...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-2-380
更新日期:1976-02-01 00:00:00
abstract::With a recently developed microdissection technique, four circumventricular organs were removed from the rat brain, and their contents of LHRH and TRH were measured. The subfornical organ, the organon vasculosum lamia terminalis, the subcommissural organ, the area postrema all contained significant quantities of both ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-2-311
更新日期:1976-02-01 00:00:00
abstract::The concentration of testosterone (T) and 5alpha-dihydrotestosterone (DHT) in plasma, seminal fluid, and epididymis of male Wistar rats have been determined by radioimmunoassay. The DHT/T ratio rose from 0.1 in blood to 1 in testicular fluid and 4 in epididymal fluid. This ratio is 2 in tissues of "caput" epididymis a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-1-111
更新日期:1976-01-01 00:00:00
abstract::Pituitary growth hormone (GH) content and plasma GH response to pentobarbital (PB) of severely hypothyroid rats are markedly decreased compared with euthyroid rats. Both pituitary and plasma GH may be increased by single ip injections of physiologic doses of thyroxine (T4) (1.75 mug/100g BW) or triiodothyronine (T3) (...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-1-77
更新日期:1976-01-01 00:00:00
abstract::Mice with the recessively inherited obese-hyperglycemic syndrome (ob/ob) and their nonobese litter mates were studied over a 26-week period. The body weights and serum glucose levels of ob/ob mice began to rise markedly at 5-6 weeks of age and remained elevated throughout the period of study. Obese mice were significa...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-1-139
更新日期:1976-01-01 00:00:00
abstract::Female rats were ovariectomized and either sham-pinealectomized or pinealectomized on day 24 of age and exposed to a photoperiod of 12 h light: 12 h dark. In vivo and in vitro measures of adrenocortical function were made at 6, 7, and 8 weeks of age (18, 25, and 32 days post-pinealectomy, respectively). Pinealectomy d...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-1-20
更新日期:1976-01-01 00:00:00
abstract::Previous studies have shown that increased sodium chloride in drinking water failed to suppress serum renin activity (SRA) in the etheranesthetized rat. In the absence of anesthesia, sodium chloride decreased SRA by 76% and serum aldosterone by 72%. Deoxycorticosterone acetate, when given alone, produced similar resul...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-6-1394
更新日期:1975-12-01 00:00:00
abstract::In male hamsters, light deprivation was reported to reduce both testis weight and prolactin (PRL) levels. Therefore, we decided to examine the effects of PRL on testicular function in hamsters exposed to short day-length. Adult hamsters were exposed to 5 h of light per day to induce gonadal atrophy, and, starting two ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:
更新日期:1975-12-01 00:00:00
abstract::Studies were undertaken to investigate the effects of synthetic 1-24 adrenocorticotropin (ACTH), bovine alpha melanocyte-stimulating hormone (alpha-MSH), and ovine beta lipotropin (beta-LPH) on plasma calcium and phosphate in rabbits. Equimolar concentrations of these hormones were infused intravenously in intact and ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-6-1593
更新日期:1975-12-01 00:00:00
abstract::Five studies are reported which were designed to define the effects of an estrogen and a progestogen, alone and in combination, on tissue concentrations (heart, kidney, and liver) of two trace metals (zinc, copper) and four bulk cations (sodium, potassium, calcium, magnesium). Male rats received Premarin (0.08 mg) and...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-5-1263
更新日期:1975-11-01 00:00:00
abstract::Complete hypothalamic deafferentation, either limited to the median eminence, arcuate nucleus, and basal parts of ventromedial nuclei, or comprising ventromedial nuclei and dorsomedial hypothalamus as well reduced considerably the rise of immunoassayable serum TSH in adult male rats rendered hypothyroid by administrat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-5-1234
更新日期:1975-11-01 00:00:00
abstract::The effect of methysergide (MES, 2.5 mg/100 g body wt), a serotonin antagonist, on prolactin release has been studied in lactating and ovariectomized rats. MES caused significant increases in prolactin release in both animals. Studies in ovariectomized, hypophysectomized rats indicate that this effect is not due to a ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-5-1096
更新日期:1975-11-01 00:00:00
abstract::Rabbit hearts perfused by the Langendorff technique were studied. The addition of ovine prolactin (NIH-P-S-10) to the perfusate in a concentration of 50 ng/ml produced rapid increases in both the amplitude and rate of contraction in 33 adult male hearts studied in winter. Prepubertal male animals showed no response, a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-4-1008
更新日期:1975-10-01 00:00:00
abstract::Hamsters injected sc with 50 mug estradiol cyclopentylpropionate (ECP) at 0900 h on day 1 (metestrus) of the cycle show the normal "postovulatory" vaginal discharge 4 days later but do not resume ovulation until 14--18 days later. After ECP injection ovarian histology reveals that the follicles normally destined to ov...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-4-878
更新日期:1975-10-01 00:00:00
abstract::The regression of the tadpole tail is under the direct control of the thyroid hormones and offers a unique system for the study of the action of these hormones. We have examined the binding of L-triiodothyronine (T3) and L-thyroxine (T4) in vitro using tail fin bricks which included epidermal and connective cells. The...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-4-1030
更新日期:1975-10-01 00:00:00
abstract::The median eminence (ME) region of the hypothalamus was electrically stimulated through permanently implanted electrodes in 1 unanesthetized sheep. Plasma concentrations of GH and prolactin (PRL) were measured at 10-min intervals before, during and after 30-min periods of electrical stimulation or sham procedures. The...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-4-808
更新日期:1975-10-01 00:00:00
abstract::The possible role of the pentose phosphate shunt in thyroid hormone secretion was investigated in vivo and in vitro with mouse thyroid glands. Thyroidal endocytosis in response to TSH, a step of thyroid hormone secretion, was evaluated for its dependency upon the pentose phosphate shunt by using 6-aminonicotinamide (6...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-4-962
更新日期:1975-10-01 00:00:00
abstract::A method has been developed for the purification of rat placental lactogen employing a specific radioreceptor assay (RRA). The method involves precipitation with ammonium sulfate, gel filtration on Sephadex G-100, ion-exchange chromatography on DEAE-cellulose and CM-Sephadex, and preparative isoelectric focusing. The ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-3-621
更新日期:1975-09-01 00:00:00
abstract::Basal hypothalamic deafferentation abolished the nycthemeral rhythm of both plasma TSH and corticosterone. ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-3-749
更新日期:1975-09-01 00:00:00